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Your Position: Home > CD8 alpha

CD8 alpha

Brief Information

Name:Cluster of differentiation 8
Target Synonym:CD8 Antigens
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CDA-HA2H5 Human Alexa Fluor™ 647-Labeled Human CD8 alpha Protein, His TagStar Staining
CDA-HA2H4 Human Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His TagStar Staining
CDA-HA2H6 Human Alexa Fluor™ 488-Labeled Human CD8 alpha Protein, His Tag
CDA-HA2H6-structure
CDA-HA2H6-sds
CDA-C82E7 Cynomolgus Biotinylated Cynomolgus CD8 alpha / CD8A Protein, His,Avitag™ (MALS verified)
CDA-C82E7-structure
CDA-C82E7-sds
CDA-C52H4 Cynomolgus Cynomolgus CD8 alpha / CD8A Protein, His Tag (MALS verified)
CDA-C52H4-structure
CDA-C52H4-sds
CDA-H52H3 Human Human CD8 alpha / CD8A Protein, His Tag (MALS verified)
CDA-H52H3-structure
CDA-H52H3-sds
CDA-H82E3 Human Biotinylated Human CD8 alpha / CD8A Protein, His,Avitag™
CDA-H82E3-structure
CDA-H82E3-sds
CDA-M82E8 Mouse Biotinylated Mouse CD8 alpha / CD8A Protein, His,Avitag™
CDA-M82E8-structure
CDA-M82E8-sds
ACRO Quality

Part of Bioactivity data

CDA-H52H3-ELISA
CD8 alpha ELISA

Immobilized Human CD8 alpha, His Tag (Cat. No. CDA-H52H3) at 5 μg/mL (100 μL/well) can bind Anti-CD8 alpha Antibody, Human IgG1 with a linear range of 1-2 ng/mL (QC tested).

Protocol
CDA-C52H4-MALS-HPLC
CD8 alpha MALS images

The purity of Cynomolgus CD8 alpha Protein, His Tag (Cat. No. CDA-C52H4) is more than 95% and the molecular weight of this protein is around 46-56 kDa verified by SEC-MALS.

Synonym Name

CD8A,CD8,Leu2,MAL,p32

Background

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Clinical and Translational Updates

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